Acute generalized exanthematous pustulosis - 急性全身发疹性脓疱病
急性全身发疹性脓疱病 (Acute generalized exanthematous pustulosis) (AGEP) 是一种罕见的皮肤反应，约90% 的病例与药物使用有关。该疾病的特点是用药后平均约五天出现突发性皮疹，表现为脓疱——皮肤上出现红色或白色的小丘疹，内部含有混浊或脓性分泌物。停药后，皮肤损害通常在 1–3 天内逐渐消退。
突然出现广泛的红斑和脓疱性皮损。
relevance score : -100.0%
ReferencesAcute generalized exanthematous pustulosis (AGEP) 是一种皮肤反应，其特征是在红色皮肤基底上出现充满脓液的小丘疹。该反应常在服用某些药物（如抗生素）后出现，并可迅速蔓延至全身。停用致病药物后，症状通常在两周内消退，随后可能出现皮肤脱屑。虽然大多数病例仅局限于皮肤且预后良好，但严重病例可归类为与 Stevens-Johnson syndrome 或 toxic epidermal necrolysis 类似的严重皮肤反应。治疗主要为支持性护理，完全康复的预后通常很好。
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Recent experimental data reviewed herein are supportive of an early role of drug-induced innate immune activation and innate cytokines such as interleukin (IL)-1, IL-36, and IL-17 in the pathogenesis of AGEP. This explains the rapid onset and neutrophilic character of the cutaneous inflammation.
一名76岁的男子因这两天皮肤出现变化而来到急诊室。医生在他的躯干、手臂和腿部发现了红色斑块和凸起区域。随着时间的推移，这些斑块连接在一起，他在红色区域出现了丘疹状的肿块。测试显示白细胞计数较高，其中含有大量中性粒细胞， C-reactive protein 水平升高。
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
